Fine optimization of a dissolution dynamic nuclear polarization experimental setting for ¹³C NMR of metabolic samples

Cross-polarization for dissolution dynamic nuclear polarization.

Dynamic nuclear polarization (DNP) in combination with subsequent dissolution of the sample allows the detection of low-γ nuclei in the solution state with a signal gain of up to tens of thousand times compared to experiments starting from Boltzmann conditions. The long polarization build-up times of typically more than one hour are a drawback of this technique. The combination of dissolution D...

Optimizing dissolution dynamic nuclear polarization.

This article is a short review of some of our recent developments in dissolution dynamic nuclear polarization (d-DNP). We present the basic principles of d-DNP, and motivate our choice to step away from conventional approaches. We then introduce a modified d-DNP recipe that can be summed up as follows. (i) Using broad line polarizing agents to efficiently polarize 1H spins. (ii) Increasing the ...

A benzyl alcohol derivative of the BDPA radical for fast dissolution dynamic nuclear polarization NMR spectroscopy.

The synthesis, structural characterization and the successful application of a carbon centered radical derived from 1,3-bisdiphenylene-2-phenylallyl (BDPA), its benzyl alcohol derivative (BA-BDPA), as a polarizing agent for Dynamic Nuclear Polarization (DNP) are described. The reported BA-BDPA radical meets all the requirements to become a promising candidate for its use in in vivo DNP-NMR expe...

BDPA: an efficient polarizing agent for fast dissolution dynamic nuclear polarization NMR spectroscopy.

Review: MR Physics for Clinicians Hyperpolarized C Metabolic Imaging Using Dissolution Dynamic Nuclear Polarization

GE Healthcare, Menlo Park, California, USA. GE Healthcare, Toronto, Canada. GE Healthcare, Denmark. *Address reprint requests to: R.E.H., GE Healthcare, 333 Ravenswood Ave., Menlo Park, CA 94025. E-mail: [email protected] Received November 15, 2011; Accepted June 10, 2012. DOI 10.1002/jmri.23753 View this article online at wileyonlinelibrary.com. This article is accredited as a journal-based CM...